Inflammation and DNA damage: Probing pathways to cancer and neurodegeneration

Mehran Makvandi; Mark A Sellmyer; Robert H Mach

doi:10.1016/j.ddtec.2017.11.001

Inflammation and DNA damage: Probing pathways to cancer and neurodegeneration

Drug Discov Today Technol. 2017 Nov:25:37-43. doi: 10.1016/j.ddtec.2017.11.001. Epub 2017 Nov 22.

Authors

Mehran Makvandi¹, Mark A Sellmyer¹, Robert H Mach²

Affiliations

¹ Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: rmach@mail.med.upenn.edu.

PMID: 29233266
DOI: 10.1016/j.ddtec.2017.11.001

Abstract

Cancer and neurodegeneration represent two opposite ends of the biological spectrum but contain many common biological mechanisms. Two such mechanisms include the elevated levels of oxidative stress and DNA damage. In this brief review, we describe current approaches for imaging these biological pathways with the molecular imaging technique, Positron Emission Tomography (PET), and the potential of PET imaging studies to measure the efficacy of anticancer drugs and strategies for delaying the progression of neurodegenerative disorders.

Publication types

Review

MeSH terms

Animals
Cell Death
DNA Damage
Humans
Inflammation / diagnostic imaging
Inflammation / metabolism
Neoplasms / diagnostic imaging*
Neoplasms / metabolism*
Neurodegenerative Diseases / diagnostic imaging*
Neurodegenerative Diseases / metabolism*
Poly (ADP-Ribose) Polymerase-1 / metabolism*
Positron-Emission Tomography
Reactive Oxygen Species / metabolism

Substances

Reactive Oxygen Species
Poly (ADP-Ribose) Polymerase-1