Biological evaluation of new imidazole derivatives tethered with indole moiety as potent α-glucosidase inhibitors

Sadia Naureen; Faryal Chaudhry; Munawar Ali Munawar; Muhammad Ashraf; Sujhla Hamid; Misbahul Ain Khan

doi:10.1016/j.bioorg.2017.12.014

Biological evaluation of new imidazole derivatives tethered with indole moiety as potent α-glucosidase inhibitors

Bioorg Chem. 2018 Feb:76:365-369. doi: 10.1016/j.bioorg.2017.12.014. Epub 2017 Dec 5.

Authors

Sadia Naureen¹, Faryal Chaudhry², Munawar Ali Munawar³, Muhammad Ashraf⁴, Sujhla Hamid⁴, Misbahul Ain Khan⁵

Affiliations

¹ Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan; Govt Post Graduate Islamia College for Women, Cooper Road, Lahore, Pakistan. Electronic address: phdline123@yahoo.com.
² Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan; Kinnaird College for Women, Lahore, Pakistan.
³ Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan.
⁴ Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
⁵ Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan; Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.

PMID: 29232634
DOI: 10.1016/j.bioorg.2017.12.014

Abstract

A series of triarylimidazoles substituted with 2-arylindoles (4a-4j) were prepared and evaluated for their in vitro α-Glucosidase inhibition. α-Glucosidase inhibition assay displayed a new class of highly potent agents The new compounds showed significant α-glucosidase inhibitory activity as compared to the standard inhibitor acrabose. Structures of synthesized compounds were determined by using Mass spectrometry FT-IR, ¹H NMR and ¹³C NMR.

Keywords: 2-Arylindoles; Diabetes; Multicomponent reactions; NMR spectra; α-Glucosidase inhibition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Assays
Glycoside Hydrolase Inhibitors / chemical synthesis
Glycoside Hydrolase Inhibitors / chemistry*
Imidazoles / chemical synthesis
Imidazoles / chemistry*
Indoles / chemical synthesis
Indoles / chemistry*
Molecular Structure

Substances

Glycoside Hydrolase Inhibitors
Imidazoles
Indoles