Glut3 Addiction: A Druggable Vulnerability in Glioblastoma

Severa Bunda; Gelareh Zadeh; Kenneth D Aldape

doi:10.1016/j.ccell.2017.11.017

Glut3 Addiction: A Druggable Vulnerability in Glioblastoma

Cancer Cell. 2017 Dec 11;32(6):726-727. doi: 10.1016/j.ccell.2017.11.017.

Authors

Severa Bunda¹, Gelareh Zadeh¹, Kenneth D Aldape²

Affiliations

¹ Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
² Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. Electronic address: kaldape@gmail.com.

PMID: 29232550
DOI: 10.1016/j.ccell.2017.11.017

Abstract

The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggable vulnerability in a subpopulation of GBM.

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MeSH terms

Adult
Brain Neoplasms*
Glioblastoma*
Humans