Susceptibility of HLA-E*01:03 Allele Carriers to Develop Cytomegalovirus Replication After Living-Donor Kidney Transplantation

J Infect Dis. 2018 May 25;217(12):1918-1922. doi: 10.1093/infdis/jix638.

Abstract

Cytomegalovirus (CMV) causes serious complications among solid organ transplant recipients. We report the positive correlation between the presence of the HLA-E*01:03 allele in living-donor kidney recipients and CMV reactivation during the first year after transplantation. Thus, HLA-E genotyping may help identify CMV replication-prone patients who require individualized patient-based CMV management.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Cytomegalovirus / pathogenicity*
  • Cytomegalovirus Infections / genetics*
  • Female
  • HLA-E Antigens
  • Histocompatibility Antigens Class I / genetics*
  • Humans
  • Kidney Transplantation / methods
  • Living Donors
  • Male
  • Middle Aged
  • Transplant Recipients
  • Virus Replication / genetics*

Substances

  • Histocompatibility Antigens Class I