[In vitro oogenesis: How far have we come?]

Abstract

Oogenesis is a complex cellular and molecular process whose fundamental mechanisms are still poorly described or not yet elucidated, especially in human species. The development of an in vitro model of oogenesis, particularly during fetal development in humans, is a critical step that would allow: (i) a better understand of the biological mechanisms of oogenesis; (ii) a refinement of medical diagnosis for women suffering from infertility; and (iii) providing new therapeutics for reproductive pathologies. The genesis of this model could be considered from ES/iPS cells. In this article, we will trace the physiological mechanisms of oogenesis in vivo and discuss the studies carried out in the field of in vitro oogenesis from ES/iPS cells, as well as the challenges to be met in the future.

Keywords: ESC/iPSC; In vitro; Oogenesis; Ovogenèse; PGC-LC.