Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life-saving treatment

Clin Case Rep. 2017 Oct 9;5(12):1926-1930. doi: 10.1002/ccr3.1214. eCollection 2017 Dec.

Abstract

Drug-induced aHUS is rare; however, early diagnosis is vital to reduce morbidity and mortality. With confirmation of the diagnosis, eculizumab appears to be a viable treatment option to suppress the pro-inflammatory surge. Furthermore, adverse side effects of medications such as carfilzomib and gemcitabine should be considered in the appropriate settings.

Keywords: Carfilzomib; eculizumab; gemcitabine; hemolytic–uremic syndrome; thrombotic microangiopathy; thrombotic thrombocytopenia purpura.

Publication types

  • Case Reports