Abstract
Steroid receptor co-activator3 (SRC3) has been known to severe as an androgen receptor (AR) coactivator and is involved in the prostate cancer progression. Non-coding RNA (ncRNA) plays an important role in the cancer progression. However, the mechanism underlying the relationship between ncRNA and AR coactivators is still unclear. Here, we found a ncRNA, Nuclear Enriched Abundant Transcript 1 (NEAT1), was able to interact with SRC3 in the prostate cancer cell lines. NEAT1 can upregulate the AKT phosphorylation via a SRC3/IGF1R pathway. In function, NEAT1 promoted the prostate cancer cell growth through IGF1R/AKT signaling pathway. The NEAT1, SRC3, and IGF1R were highly expressed in the patients' samples of prostate cancer. Therefore, we found a novel SRC3 binding ncRNA that can promote the prostate cancer cell growth through SRC3/IGF1R/AKT pathway.
Keywords:
IGF1R; NEAT1; Prostate cancer; SRC3.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Cell Proliferation
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Gene Expression Regulation, Neoplastic
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Humans
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Male
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Middle Aged
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Neoplasm Proteins / agonists
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Neoplasm Proteins / metabolism
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Neoplasm Staging
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Nuclear Receptor Coactivator 3 / agonists*
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Nuclear Receptor Coactivator 3 / metabolism
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Phosphorylation
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Prostate / enzymology
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Prostate / metabolism
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Prostate / pathology
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Prostatic Neoplasms / enzymology
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Prostatic Neoplasms / metabolism*
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Prostatic Neoplasms / pathology
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Protein Multimerization
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Protein Processing, Post-Translational
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Proto-Oncogene Proteins c-akt / agonists*
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Proto-Oncogene Proteins c-akt / metabolism
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RNA Interference
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RNA, Long Noncoding / antagonists & inhibitors
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RNA, Long Noncoding / metabolism*
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RNA, Neoplasm / antagonists & inhibitors
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RNA, Neoplasm / metabolism*
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Receptor, IGF Type 1
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Receptors, Somatomedin / agonists*
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Receptors, Somatomedin / antagonists & inhibitors
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Receptors, Somatomedin / genetics
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Receptors, Somatomedin / metabolism
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Signal Transduction*
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Tissue Banks
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Tumor Cells, Cultured
Substances
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IGF1R protein, human
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NEAT1 long non-coding RNA, human
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Neoplasm Proteins
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RNA, Long Noncoding
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RNA, Neoplasm
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Receptors, Somatomedin
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NCOA3 protein, human
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Nuclear Receptor Coactivator 3
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Receptor, IGF Type 1
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AKT1 protein, human
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Proto-Oncogene Proteins c-akt