Povidone iodine soaked gelfoam for the treatment of recalcitrant otomycosis - Our experiences at a tertiary care teaching hospital of eastern India

J Mycol Med. 2018 Mar;28(1):122-127. doi: 10.1016/j.mycmed.2017.11.006. Epub 2017 Dec 7.

Abstract

Introduction: Otomycosis is a common clinical condition seen in outpatient department of otorhinolaryngology. The treatment of the otomycosis is also very simple. However, sometime it is difficult to treat otomycosis along with mastoid cavity, chronic suppurative otitis media, immunocompromised patient, etc. with conventional treatment, called recalcitrant otomycosis. Here, we describe a technique of treatment for recalcitrant otomycosis.

Materials and methods: This is a prospective observational study/clinical trial carried out on 44 patients of recalcitrant otomycosis. They are divided into two groups, each of 22. One group treated with routine clotrimazole topical eardrops whereas other group treated with povidone iodine soaked gelfoam, placed in the external auditory canal.

Results: There was no significance difference according to the age (P=0.134), gender (P=0.760) and causative agents (P=0.750) between treatment groups. The resolution of the symptoms showed statistically significant on itching (P=0.0001), otorrhoea (P=0.0033), fullness (P=0.0432) and earache (P=0.0259), whereas no statistical significant on hearing loss (P=0.0683), when treating with povidone iodine soaked gelfoam as compared to routine (clotrimazole) treatment. Resolution of signs like canal wall erythema (P=0.0045), tragal tenderness (P=0.0012) and congestion of tympanic membrane (P=0.0088) is statistically significant when comparing clotrimazole with povidone iodine. Apart from these, we did not reveal any adverse effects from the study populations treated with povidone iodine soaked gelfoam.

Conclusion: Use of the povidone iodine soaked gelfoam at the external auditory canal in recalcitrant otomycosis is an effective and well-tolerated treatment.

Keywords: Gelfoam; Otomycosis; Povidone iodine; Topical eardrops.

Publication types

  • Clinical Trial
  • Observational Study

MeSH terms

  • Administration, Topical*
  • Adolescent
  • Adult
  • Aged
  • Antifungal Agents / therapeutic use
  • Clotrimazole / therapeutic use
  • Female
  • Gelatin Sponge, Absorbable / chemistry
  • Gelatin Sponge, Absorbable / pharmacology*
  • Hearing
  • Hospitals, Teaching / statistics & numerical data
  • Humans
  • Immunocompromised Host
  • India / epidemiology
  • Male
  • Middle Aged
  • Otomycosis / drug therapy*
  • Otomycosis / epidemiology
  • Otomycosis / microbiology
  • Otomycosis / physiopathology
  • Povidone-Iodine / pharmacology*
  • Prospective Studies
  • Tertiary Healthcare / statistics & numerical data
  • Young Adult

Substances

  • Antifungal Agents
  • Povidone-Iodine
  • Clotrimazole