Fighting Resilient Cancers with Iron

Jonathan J Chen; Lorenzo Galluzzi

doi:10.1016/j.tcb.2017.11.007

Fighting Resilient Cancers with Iron

Trends Cell Biol. 2018 Feb;28(2):77-78. doi: 10.1016/j.tcb.2017.11.007. Epub 2017 Dec 7.

Authors

Jonathan J Chen¹, Lorenzo Galluzzi²

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
² Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Université Paris Descartes/Paris V, Paris, France. Electronic address: deadoc@vodafone.it.

PMID: 29223642
DOI: 10.1016/j.tcb.2017.11.007

Abstract

Tumor progression and resistance to treatment are often accompanied by the polarization of malignant cells towards a mesenchymal or poorly differentiated state. Such a transition generates an accrued vulnerability to the induction of ferroptosis, potentially paving the way to novel therapeutic strategies for targeting residual disease in patients with cancer.

Keywords: epithelial-to-mesenchymal transition; glutathione; lipid peroxidation; polyunsaturated fatty acids; regulated cell death; statins.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / metabolism*
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use
Apoptosis / drug effects
Apoptosis / physiology*
Cell Death / drug effects
Cell Death / physiology
Cell Differentiation / drug effects
Cell Differentiation / physiology
Drug Resistance, Neoplasm / drug effects
Drug Resistance, Neoplasm / physiology*
Glutathione Peroxidase / antagonists & inhibitors
Glutathione Peroxidase / metabolism
Humans
Iron / metabolism*
Neoplasms / drug therapy
Neoplasms / metabolism*
Neoplasms / pathology
Phospholipid Hydroperoxide Glutathione Peroxidase

Substances

Antineoplastic Agents
Iron
Phospholipid Hydroperoxide Glutathione Peroxidase
Glutathione Peroxidase