New insights into the influence of monofluorination on dimyristoylphosphatidylcholine membrane properties: A solid-state NMR study

Marie-Claude Gagnon; Erik Strandberg; Anne S Ulrich; Jean-François Paquin; Michèle Auger

doi:10.1016/j.bbamem.2017.12.002

New insights into the influence of monofluorination on dimyristoylphosphatidylcholine membrane properties: A solid-state NMR study

Biochim Biophys Acta Biomembr. 2018 Mar;1860(3):654-663. doi: 10.1016/j.bbamem.2017.12.002. Epub 2017 Dec 7.

Authors

Marie-Claude Gagnon¹, Erik Strandberg², Anne S Ulrich³, Jean-François Paquin⁴, Michèle Auger⁵

Affiliations

¹ Department of Chemistry, PROTEO, CGCC, 1045 avenue de la Médecine, Université Laval, Québec G1V 0A6, Canada; Department of Chemistry, PROTEO, CERMA, CQMF, 1045 avenue de la Médecine, Université Laval, Québec G1V 0A6, Canada.
² Karlsruhe Institute of Technology (KIT), Institute of Biological Interfaces (IBG-2), POB 3640, 76021 Karlsruhe, Germany.
³ Karlsruhe Institute of Technology (KIT), Institute of Biological Interfaces (IBG-2), POB 3640, 76021 Karlsruhe, Germany; KIT, Institute of Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
⁴ Department of Chemistry, PROTEO, CGCC, 1045 avenue de la Médecine, Université Laval, Québec G1V 0A6, Canada. Electronic address: jean-francois.paquin@chm.ulaval.ca.
⁵ Department of Chemistry, PROTEO, CERMA, CQMF, 1045 avenue de la Médecine, Université Laval, Québec G1V 0A6, Canada. Electronic address: michele.auger@chm.ulaval.ca.

PMID: 29223532
DOI: 10.1016/j.bbamem.2017.12.002

No abstract available

Keywords: Eukaryotic model membranes; Fluorine-labeled DMPC; Helical antimicrobial peptides; NMR reporter group; Solid-state (2)H, (15)N, (19)F and (31)P NMR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dimyristoylphosphatidylcholine / chemistry*
Fluorine / chemistry
Halogenation*
Isotope Labeling / methods*
Lipid Bilayers / chemistry
Membrane Lipids / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular / methods*
Oligopeptides / chemistry
Peptide Fragments / chemistry
Peptides / chemistry

Substances

Lipid Bilayers
Membrane Lipids
Oligopeptides
Peptide Fragments
Peptides
magainin-PGLa hybrid peptide
Fluorine
Dimyristoylphosphatidylcholine