CRISPR-Based Gene Drives for Pest Control

Trends Biotechnol. 2018 Feb;36(2):130-133. doi: 10.1016/j.tibtech.2017.10.001.

Abstract

Clustered regularly interspaced short palindromic repeats (CRISPR)-based gene drives (GDs) could be used to spread desirable genetic elements through wild populations. With the imminent development of this technology in vertebrates, we believe that it is timely to highlight two forms of sex-ratio distorting GDs that show potential as pest management tools.

Keywords: CRISPR; gene drive; genetic engineering; pest control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • CRISPR-Associated Protein 9
  • CRISPR-Cas Systems*
  • Endonucleases / genetics
  • Endonucleases / metabolism
  • Gene Drive Technology / methods*
  • Gene Editing / methods*
  • Genetic Engineering / methods
  • Introduced Species
  • Pest Control / methods*
  • RNA, Guide, CRISPR-Cas Systems / genetics
  • RNA, Guide, CRISPR-Cas Systems / metabolism
  • Rodentia / genetics
  • Sex Ratio

Substances

  • Bacterial Proteins
  • RNA, Guide, CRISPR-Cas Systems
  • CRISPR-Associated Protein 9
  • Cas9 endonuclease Streptococcus pyogenes
  • Endonucleases