'AIE + ESIPT' assisted photorelease: fluorescent organic nanoparticles for dual anticancer drug delivery with real-time monitoring ability

Chem Commun (Camb). 2017 Dec 21;54(2):168-171. doi: 10.1039/c7cc07692d.

Abstract

'Aggregation Induced Emission + Excited State Intramolecular Proton Transfer (AIE + ESIPT)'-assisted photorelease of an anticancer drug by a p-hydroxyphenacyl (pHP) phototrigger with real-time monitoring has been demonstrated.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Survival / drug effects
  • Drug Delivery Systems*
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / pharmacology
  • HeLa Cells
  • Humans
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Phenylacetates / chemistry*
  • Phenylacetates / pharmacology
  • Photochemical Processes
  • Protons*
  • Time Factors

Substances

  • Antineoplastic Agents
  • Fluorescent Dyes
  • Phenylacetates
  • Protons
  • 4-hydroxyphenylacetic acid