Technical aspects of microphysiological systems (MPS) as a promising wet human-in-vivo simulator

Toshiyuki Kanamori; Shinji Sugiura; Yasuyuki Sakai

doi:10.1016/j.dmpk.2017.11.006

Technical aspects of microphysiological systems (MPS) as a promising wet human-in-vivo simulator

Drug Metab Pharmacokinet. 2018 Feb;33(1):40-42. doi: 10.1016/j.dmpk.2017.11.006. Epub 2017 Nov 23.

Authors

Toshiyuki Kanamori¹, Shinji Sugiura², Yasuyuki Sakai³

Affiliations

¹ Drug Assay Device Research Group, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8565, Tokyo, Japan. Electronic address: t.kanamori@aist.go.jp.
² Drug Assay Device Research Group, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8565, Tokyo, Japan. Electronic address: shinji.sugiura@aist.go.jp.
³ Department of Chemical System Engineering, Graduate School of Engineering, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8656, Japan; International Research Center on Integrative Biomedical Systems (CIBiS), Institute of Industrial Science, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo, 153-8505, Japan. Electronic address: sakaiyasu@chemsys.t.u-tokyo.ac.jp.

PMID: 29217459
DOI: 10.1016/j.dmpk.2017.11.006

Abstract

Microphysiological systems (MPS) are currently attracting a lot of interest from pharmaceutical companies worldwide. In the United States and European Union, several large government projects related to MPS have been initiated, and, in Japan, pharmaceutical companies interested in MPS are watching the recent trends and developments in the field. In July 2017, the Japan Agency for Medical Research and Development initiated a research program to develop chip-based MPS. In this review, we examine the technical aspects of commercializing chip-based MPS.

Keywords: Cell-based assay; Microenvironments; Microfluidics; Organ-specific function; Standardization; iPS cells.

Publication types

Review

MeSH terms

Drug Evaluation, Preclinical / methods*
Drug Industry / methods
Drug Industry / trends*
Humans
Pharmaceutical Preparations / administration & dosage
Pharmaceutical Preparations / metabolism*
Physiological Phenomena / drug effects
Physiological Phenomena / physiology*
Protein Array Analysis / methods
Protein Array Analysis / trends*

Substances

Pharmaceutical Preparations