Panomics for Precision Medicine

Trends Mol Med. 2018 Jan;24(1):85-101. doi: 10.1016/j.molmed.2017.11.001. Epub 2017 Dec 5.

Abstract

Medicine is poised to undergo a digital transformation. High-throughput platforms are creating terabytes of genomic, transcriptomic, proteomic, and metabolomic data. The challenge is to interpret these data in a meaningful manner - to uncover relationships that are not readily apparent between molecular profiles and states of health or disease. This will require the development of novel data pipelines and computational tools. The combined analysis of multi-dimensional data is referred to as 'panomics'. The ultimate hope of integrative panomics is that it will lead to the discovery and application of novel markers and targeted therapeutics that drive forward a new era of 'precision medicine' where inter-individual variation is accounted for in the treatment of patients.

Keywords: genomics; metabolomics; panomics; precision medicine; proteomics; transcriptomics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Epigenesis, Genetic
  • Genomics / methods*
  • Humans
  • Metabolomics / methods*
  • Precision Medicine / methods*
  • Sequence Analysis, RNA / methods
  • Single-Cell Analysis / methods
  • Transcriptome