The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity

Nat Med. 2017 Dec 7;23(12):1394-1396. doi: 10.1038/nm.4442.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Chlorides / metabolism
  • HEK293 Cells
  • Humans
  • K Cl- Cotransporters
  • Patch-Clamp Techniques
  • Protein Binding
  • Receptors, GABA-A / drug effects*
  • Symporters / drug effects*
  • Symporters / metabolism
  • Thallium / pharmacology
  • Thiazolidines / pharmacology*
  • Transfection

Substances

  • CLP257
  • Chlorides
  • Receptors, GABA-A
  • Symporters
  • Thiazolidines
  • Thallium