Electrochemical Synthesis of Aryl Iodides by Anodic Iododesilylation

Abstract

An electrochemical access to iodinated aromatic compounds starting from trimethylsilyl-substituted arenes is presented. By design of experiments, highly efficient and mild conditions were identified for a wide range of substrates. A functional group stability test and the synthesis of an important 3-iodobenzylguanidine radiotracer illustrate the scope of this process.

Keywords: arenes; compatibility test; design of experiments; electrochemistry; iododesilylation.