Polymorphisms of rs1347093 and rs1397529 are associated with lung cancer risk in northeast Chinese population

Xiaoying Li; XueLian Li; Yangwu Ren; Zhihua Yin; Xiaowei Quan; Xiaoxia Xue; Baosen Zhou

doi:10.18632/oncotarget.22030

Polymorphisms of rs1347093 and rs1397529 are associated with lung cancer risk in northeast Chinese population

Oncotarget. 2017 Oct 24;8(55):94862-94871. doi: 10.18632/oncotarget.22030. eCollection 2017 Nov 7.

Authors

Xiaoying Li^{1

2}, XueLian Li^{1

2}, Yangwu Ren^{1

2}, Zhihua Yin^{1

2}, Xiaowei Quan^{1

2}, Xiaoxia Xue³, Baosen Zhou^{1

2}

Affiliations

¹ Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
² Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Department of Education, Liaoning, China.
³ The Third Center of Laboratory Technology and Experimental Medicine, China Medical University, Shenyang, China.

Abstract

Lung cancer is one of the malignant tumors with the highest morbidity and mortality all over the world. Here we researched the association between two SNPs (rs1347093 in MIR217HG and rs1397529 in Gab1) and the risk of lung cancer in northeast Chinese population, including 825 cases and 766 controls. We carried out χ² test, unconditional logistic regression analysis and crossover analysis to estimate the relationship between SNPs and lung cancer risk and the interaction between SNPs and smoking on susceptibility to lung cancer. The results indicated that rs1347093, rs1397529 polymorphisms were associated with lung cancer risk, especially with adenocarcinoma risk. Dominant genetic model of the rs1347093 was associated with reduced risk of lung cancer compared to CC genotype (AC+AA vs. CC: adjusted OR = 0.599, 95%CI = 0.418-0.858, P=0.005). For rs1347093, the similar result was found. Dominant genetic model of the rs1397529 was associated with reduced risk of lung cancer compared to AA genotype (AC+CC vs. AA: adjusted OR = 0.664, 95%CI = 0.491-0.897, P=0.008). There is no significant interaction between rs1347093, rs1397529 polymorphism and smoking on susceptibility to lung cancer. Our study might demonstrate that rs1347093 in MIR217HG and rs1397529 in Gab1 could be meaningful as the novel biomarker for lung cancer risk.

Keywords: Gab1; MIR217HG; lung cancer; single nucleotide polymorphisms; susceptibility.