Nevus spilus is a melanocytic neoplasm characterized by a tan macular background punctuated by multiple hyperpigmented macules or papules that represent various types of nevi. These include junctional and compound nevi, Spitz nevi, and rarely blue nevi. We report a unique case of widespread, multiple nevi spili giving rise to agminated Spitz nevi and congenital-pattern compound nevi. We performed genetic analysis to further characterize the mutational profile of this rare entity.
Keywords: HRAS; Spitz nevus; congenital nevus; genomics; nevus spilus.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.