Ionic signalling and mitochondrial dynamics

Nada Abuarab; Fangfang Li; Asipu Sivaprasadarao

doi:10.1080/23723556.2017.1373889

Ionic signalling and mitochondrial dynamics

Mol Cell Oncol. 2017 Sep 18;4(6):e1373889. doi: 10.1080/23723556.2017.1373889. eCollection 2017.

Authors

Nada Abuarab¹, Fangfang Li¹, Asipu Sivaprasadarao^{1

2}

Affiliations

¹ School of Biomedical Sciences, Faculty of Biological Sciences, LS2 9JT, Leeds, U.K.
² Multidisciplinary Cardiovascular Research Centre, University of Leeds, LS2 9JT, Leeds, U.K.

Abstract

In age-related diseases, rise in intracellular reactive oxygen species (ROS) causes fragmentation of mitochondrial network. Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysosomal Zn²⁺ release that, in turn, triggers mitochondrial fragmentation. The findings provide new mechanistic insights that may have therapeutic implications.

Keywords: TRPM2; calcium; cell migration; cell proliferation; lysosomal membrane permeabilisation; mitochondrial dynamics; oxidative stress; reactive oxygen species; zinc.