New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis

Jieli Shen; Daisy F Rangel; Dat Ha; Amy S Lee

doi:10.1080/23723556.2017.1345350

New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis

Mol Cell Oncol. 2017 Jun 30;4(6):e1345350. doi: 10.1080/23723556.2017.1345350. eCollection 2017.

Authors

Jieli Shen¹, Daisy F Rangel¹, Dat Ha¹, Amy S Lee¹

Affiliation

¹ Department of Biochemistry and Molecular Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Abstract

Metaplasia is emerging as a key process in tumorigenesis. We discovered that 2 essential endoplasmic reticulum (ER) chaperones, 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) have a role in metaplasia. Grp78 haploinsufficiency in the mouse pancreas impairs acinar-to-ductal metaplasia, whereas in the uterus, Grp94 loss induces squamous cell metaplasia; both resulting in tumor suppression.

Keywords: ER chaperone; GRP78; GRP94; metaplasia; mouse models; pancreatic cancer.

Abstract

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