Evaluation of the Efficacy of Ultrasound-Guided Local Lauromacrogol Injection Combined with Aspiration for Cesarean Scar Pregnancy: A Novel Treatment

Gynecol Obstet Invest. 2018;83(3):306-312. doi: 10.1159/000485099. Epub 2017 Nov 28.

Abstract

Objectives: To evaluate the efficacy of ultrasound-guided local lauromacrogol injection combined with aspiration for treating cesarean scar pregnancy (CSP).

Methods: From July 2016 to December 2016, 18 patients diagnosed with CSP were treated with ultrasound-guided local lauromacrogol injection combined with aspiration. Clinical data and outcome were analysed.

Results: All patients were treated successfully. The amount of bleeding ranged between 10 and 50 mL. The duration of hospitalization ranged between 2 and 11 days. Serum β-human chorionic gonadotropin (β-hCG) decreased to the nondetectable level within 19-41 days. Menstruation recovery occurred after 10-24 days of normalization of serum β-hCG level. Reproductive functions were preserved, and there were no untoward effects or complications.

Conclusions: Ultrasound-guided local lauromacrogol injection combined with aspiration is an effective CSP therapy, as it was associated with a high success rate, short hospitalization and fast recovery. However, its wider application and popularization have to be validated on a larger patient population affected by CSP.

Keywords: Aspiration; Cesarean scar pregnancy; Lauromacrogol; Ultrasound.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Cesarean Section / adverse effects
  • Chorionic Gonadotropin, beta Subunit, Human / blood
  • Cicatrix* / etiology
  • Detergents / administration & dosage*
  • Female
  • Humans
  • Paracentesis / methods*
  • Polidocanol
  • Polyethylene Glycols / administration & dosage*
  • Pregnancy
  • Pregnancy, Ectopic / blood
  • Pregnancy, Ectopic / etiology
  • Pregnancy, Ectopic / therapy*
  • Retrospective Studies
  • Treatment Outcome
  • Ultrasonography, Interventional / methods*

Substances

  • Chorionic Gonadotropin, beta Subunit, Human
  • Detergents
  • Polidocanol
  • Polyethylene Glycols