Hepatitis A outbreak in HIV-infected MSM and in PrEP-using MSM despite a high level of immunity, Lyon, France, January to June 2017

Euro Surveill. 2017 Nov;22(48):17-00742. doi: 10.2807/1560-7917.ES.2017.22.48.17-00742.

Abstract

Since 2016, an increase in the number of hepatitis A cases affecting mainly men who have sex with men (MSM) has been reported in low endemic countries in Europe. We calculated the attack rate in Lyon, France, in populations considered at high-risk: HIV-infected MSM and HIV-negative MSM receiving HIV pre-exposure prophylaxis (PrEP). In these populations, high level of immunity did not prevent the outbreak, indicating that vaccination should be reinforced, particularly in younger individuals.

Keywords: Hepatitis A; hepatitis A virus; human immunodeficiency virus - HIV; men who have sex with men - MSM; outbreaks; preexposure prophylaxis - PrEP; sexually transmitted disease - STD.

MeSH terms

  • Adult
  • Anti-HIV Agents / administration & dosage*
  • Anti-HIV Agents / therapeutic use
  • Disease Outbreaks
  • Disease Transmission, Infectious / prevention & control*
  • France / epidemiology
  • HIV Infections / drug therapy*
  • HIV Infections / epidemiology
  • HIV Infections / prevention & control*
  • HIV Infections / transmission
  • Hepatitis A / diagnosis
  • Hepatitis A / epidemiology*
  • Homosexuality, Male*
  • Humans
  • Male
  • Middle Aged
  • Pre-Exposure Prophylaxis*

Substances

  • Anti-HIV Agents