Isogloiosiphone B, a novel acetal, and hydrophobic compounds as β-glucuronidase inhibitors derived from the red alga Neodilsea yendoana

Biosci Biotechnol Biochem. 2018 Jan;82(1):46-48. doi: 10.1080/09168451.2017.1403885. Epub 2017 Dec 6.

Abstract

A novel acetal named isogloiosiphone B was isolated from the red alga Neodilsea yendoana, along with three known hydrophobic compounds as β-glucuronidase inhibitors. The acetal was determined as a naturally occurring compound from the extraction experiments with several kinds of solvent. The acetal showed the highest inhibition against β-glucuronidase among the compounds examined.

Keywords: Acetal; Neodilsea yendoana; alga; inhibitor; β-glucuronidase.

MeSH terms

  • Acetals / chemistry*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Glycoproteins / chemistry*
  • Glycoproteins / pharmacology
  • Hydrophobic and Hydrophilic Interactions
  • Molecular Structure
  • Rhodophyta / chemistry*

Substances

  • Acetals
  • Enzyme Inhibitors
  • Glycoproteins
  • beta-glucuronidase inhibitor