Forcing Entry into the Nucleus

Alexis Lomakin; Guilherme Nader; Matthieu Piel

doi:10.1016/j.devcel.2017.11.015

Forcing Entry into the Nucleus

Dev Cell. 2017 Dec 4;43(5):547-548. doi: 10.1016/j.devcel.2017.11.015.

Authors

Alexis Lomakin¹, Guilherme Nader², Matthieu Piel³

Affiliations

¹ King's College London, Guy's Campus, Centre for Stem Cells & Regenerative Medicine, 28th Floor, Tower Wing, Great Maze Pond, London SE1 9RT, UK; Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France; Institut Pierre-Gilles de Gennes, PSL Research University, 75005 Paris, France.
² Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France; Institut Pierre-Gilles de Gennes, PSL Research University, 75005 Paris, France.
³ Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France; Institut Pierre-Gilles de Gennes, PSL Research University, 75005 Paris, France. Electronic address: matthieu.piel@curie.fr.

PMID: 29207257
DOI: 10.1016/j.devcel.2017.11.015

Abstract

Nuclear pore complexes tightly regulate nucleo-cytoplasmic transport, controlling the nuclear concentration of several transcription factors. In a recent issue of Cell, Elosegui-Artola et al. (2017) show that nuclear deformation modulates the nuclear entry rates of YAP/TAZ via nuclear pore stretching, clarifying how forces affect gene transcription.

Publication types

Review
Comment

MeSH terms

Active Transport, Cell Nucleus / physiology*
Adaptor Proteins, Signal Transducing / metabolism*
Animals
Cell Nucleus / metabolism*
Humans
Nuclear Pore / metabolism
Phosphoproteins / metabolism
Transcription Factors / metabolism*

Substances

Adaptor Proteins, Signal Transducing
Phosphoproteins
Transcription Factors