Immunotherapy for Prostate Cancer: Where We Are Headed

Int J Mol Sci. 2017 Dec 5;18(12):2627. doi: 10.3390/ijms18122627.

Abstract

Prostate cancer is one of the most common malignant neoplasms in men worldwide, and is the fifth cause of cancer-related death. In recent years, a new generation of therapies have been approved for the management of metastatic disease. Moreover, the development of new immunotherapeutic drugs has become a novel frontier for the treatment of several tumor types; to date, numerous studies have investigated their potential activity, including in prostate cancer. In this article, we discuss the role of emerging immunotherapeutic drugs in prostate cancer patients.

Keywords: CTLA4; PD-L1; PD1; antibodies; immunotherapy; prostate cancer; vaccines.

Publication types

  • Review

MeSH terms

  • Animals
  • Cancer Vaccines / therapeutic use
  • Humans
  • Immunotherapy / methods*
  • Male
  • Prostatic Neoplasms / drug therapy
  • Prostatic Neoplasms / immunology*
  • Prostatic Neoplasms / prevention & control

Substances

  • Cancer Vaccines