Restoration of anatomical continuity after spinal cord transection depends on Wnt/β-catenin signaling in larval zebrafish

Daniel Wehner; Thomas Becker; Catherina G Becker

doi:10.1016/j.dib.2017.10.068

Restoration of anatomical continuity after spinal cord transection depends on Wnt/β-catenin signaling in larval zebrafish

Data Brief. 2017 Nov 4:16:65-70. doi: 10.1016/j.dib.2017.10.068. eCollection 2018 Feb.

Authors

Daniel Wehner¹, Thomas Becker¹, Catherina G Becker¹

Affiliation

¹ Centre for Neuroregeneration, University of Edinburgh, The Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.

Abstract

This data article contains descriptive and experimental data on spinal cord regeneration in larval zebrafish and its dependence on Wnt/β-catenin signaling. Analyzing spread of intraspinally injected fluorescent dextran showed that anatomical continuity is rapidly restored after complete spinal cord transection. Pharmacological interference with Wnt/β-catenin signaling (IWR-1) impaired restoration of spinal continuity. For further details and experimental findings please refer to the research article by Wehner et al. Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish (Wehner et al., 2017) [1].

Keywords: Beta-catenin; Regeneration; Spinal cord; Wnt; Zebrafish.