Klebsiella pneumoniae co-producing KPC and RmtG, finally targeting Switzerland

Stefano Mancini; Laurent Poirel; Myriam Corthesy; Gilbert Greub; Patrice Nordmann

doi:10.1016/j.diagmicrobio.2017.10.019

Klebsiella pneumoniae co-producing KPC and RmtG, finally targeting Switzerland

Diagn Microbiol Infect Dis. 2018 Feb;90(2):151-152. doi: 10.1016/j.diagmicrobio.2017.10.019. Epub 2017 Nov 6.

Authors

Stefano Mancini¹, Laurent Poirel², Myriam Corthesy³, Gilbert Greub³, Patrice Nordmann⁴

Affiliations

¹ Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland; French INSERM European Unit, University of Fribourg (LEA-IAME), Fribourg, Switzerland; Swiss National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland.. Electronic address: stefano.mancini@unifr.ch.
² Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland; French INSERM European Unit, University of Fribourg (LEA-IAME), Fribourg, Switzerland; Swiss National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland.
³ Institute for Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland.
⁴ Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland; French INSERM European Unit, University of Fribourg (LEA-IAME), Fribourg, Switzerland; Swiss National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland.; Institute for Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland.

PMID: 29198372
DOI: 10.1016/j.diagmicrobio.2017.10.019

Abstract

A carbapenem- and pan-aminoglycoside-resistant Klebsiella pneumoniae strain was isolated from a Brazilian patient hospitalized in a Swiss hospital. The clinical isolate carried genes encoding the KPC-2 carbapenemase and the RmtG 16S rRNA methyltransferase. This is the first report of a carbapenem-resistant K. pneumoniae producing RmtG in Europe.

MeSH terms

Aged
Anti-Bacterial Agents / pharmacology
Bacterial Proteins / genetics
Brazil
Cross Infection / epidemiology
Cross Infection / microbiology*
Disease Outbreaks
Drug Resistance, Multiple, Bacterial / genetics*
Humans
Klebsiella Infections / microbiology*
Klebsiella pneumoniae / drug effects
Klebsiella pneumoniae / enzymology
Klebsiella pneumoniae / genetics*
Methyltransferases / genetics
Microbial Sensitivity Tests
Switzerland

Substances

Anti-Bacterial Agents
Bacterial Proteins
Methyltransferases