Late arising T follicular helper cells cultivate the B cell crop during chronic infections

Sci Immunol. 2017 Dec 1;2(18):eaap9339. doi: 10.1126/sciimmunol.aap9339.

Authors

Shannon M Kahan¹, Allan J Zajac²

Affiliations

¹ Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-2170, USA.
² Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-2170, USA. azajac@uab.edu.

PMID: 29196451
DOI: 10.1126/sciimmunol.aap9339

Abstract

Follicular helper CD4⁺ T cells are essential for the development of neutralizing antibodies that contain chronic viral infection.

Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Publication types

Review
Comment

MeSH terms

Animals
Antibodies / immunology
B-Lymphocytes / cytology
B-Lymphocytes / immunology*
Chronic Disease
Humans
T-Lymphocytes, Helper-Inducer / cytology
T-Lymphocytes, Helper-Inducer / immunology*
Virus Diseases / immunology*

Substances

Antibodies