Organic Electronics for Point-of-Care Metabolite Monitoring

Anna-Maria Pappa; Onur Parlak; Gaetan Scheiblin; Pascal Mailley; Alberto Salleo; Roisin M Owens

doi:10.1016/j.tibtech.2017.10.022

Organic Electronics for Point-of-Care Metabolite Monitoring

Trends Biotechnol. 2018 Jan;36(1):45-59. doi: 10.1016/j.tibtech.2017.10.022. Epub 2017 Nov 28.

Authors

Anna-Maria Pappa¹, Onur Parlak², Gaetan Scheiblin³, Pascal Mailley⁴, Alberto Salleo⁵, Roisin M Owens⁶

Affiliations

¹ Department of Bioelectronics, École Nationale Supérieure des Mines, Centre Microélectronique de Provence (CMP)-École Nationale Supérieure des Mines de Saint-Étienne (EMSE), Microélectronique et Objets Communicants (MOC), 13541 Gardanne, France; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 OAS, UK; Equal contributions.
² Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA; Equal contributions.
³ Commissariat à l'Energie Atomique (CEA), Laboratoire d'Électronique des Technologies de l'Information (LETI), MINATEC Campus, 38054 Grenoble, France; Equal contributions.
⁴ Commissariat à l'Energie Atomique (CEA), Laboratoire d'Électronique des Technologies de l'Information (LETI), MINATEC Campus, 38054 Grenoble, France.
⁵ Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA.
⁶ Department of Bioelectronics, École Nationale Supérieure des Mines, Centre Microélectronique de Provence (CMP)-École Nationale Supérieure des Mines de Saint-Étienne (EMSE), Microélectronique et Objets Communicants (MOC), 13541 Gardanne, France; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 OAS, UK. Electronic address: rmo37@cam.ac.uk.

PMID: 29196057
DOI: 10.1016/j.tibtech.2017.10.022

Abstract

In this review we focus on demonstrating how organic electronic materials can solve key problems in biosensing thanks to their unique material properties and implementation in innovative device configurations. We highlight specific examples where these materials solve multiple issues related to complex sensing environments, and we benchmark these examples by comparing them to state-of-the-art commercially available sensing using alternative technologies. We have categorized our examples by sample type, focusing on sensing from body fluids in vitro and on wearable sensors, which have attracted significant interest owing to their integration with everyday life activities. We finish by describing a future trend for in vivo, implantable sensors, which aims to build on current progress from sensing in biological fluids ex vivo.

Keywords: biosensors; diagnostics; metabolites; organic electronics; point-of-care; wearable.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques / instrumentation
Biosensing Techniques / methods*
Diagnostic Tests, Routine / instrumentation
Diagnostic Tests, Routine / methods*
Electronics / instrumentation
Electronics / methods*
Humans
Metabolomics / instrumentation
Metabolomics / methods*
Point-of-Care Systems*