The topic of this Journal Club is a commentary on the article “Risk factors for MRSA colonization in the neonatal ICU: A systematic review and meta-analysis” by Matthew Washam, M.D., M.P.H.; Jon Woltmann, M.D.; Beth Haberman, M.D.; David Haslam, M.D.; and Mary Allen Staat, M.D., M.P.H., from the Cincinnati Children’s Hospital. Eleven studies that reported risk factors for MRSA colonization using non-colonized controls in subspecialty level III or IV neonatal intensive care units (NICUs) were included in the systematic review and 10 articles underwent meta-analysis. The findings of the study indicate that the most commonly reported risk factors for methicillin-resistant staphylococcus aureus (MRSA) colonization in this sample was gestational age <32 weeks and very-low birth weight (<1500 grams). Infant gender, race, inborn status, and delivery type were not significantly associated with colonization.