An immune-molecular hypothesis supporting infectious aetiopathogenesis of Kawasaki disease in children

Eur J Immunol. 2018 Mar;48(3):543-545. doi: 10.1002/eji.201747226. Epub 2018 Jan 15.

Abstract

The competitive binding between CpG-ODN (single-stranded DNA from pathogens) and HLA-B and HLA-A ligands for the inhibitory Killer Immunoglobulin-like Receptors (KIR)3DL1/2 may lead to possible hypo-sensing of pathogens and ineffective clearance. We observed an overabundance of HLA ligands for inhibitory KIR with three domains in KD subjects.

Keywords: CpG-ODN; HLA; Killer immunoglobulin-like receptors; NK cells; TLR9.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Communicable Diseases / complications
  • Communicable Diseases / genetics
  • Communicable Diseases / immunology
  • HLA Antigens / genetics
  • HLA Antigens / metabolism
  • Humans
  • Immunogenetic Phenomena
  • Ligands
  • Models, Immunological*
  • Mucocutaneous Lymph Node Syndrome / etiology*
  • Mucocutaneous Lymph Node Syndrome / genetics
  • Mucocutaneous Lymph Node Syndrome / immunology*
  • Oligodeoxyribonucleotides / immunology
  • Receptors, KIR3DL1 / metabolism
  • Receptors, KIR3DL2 / metabolism

Substances

  • CPG-oligonucleotide
  • HLA Antigens
  • KIR3DL1 protein, human
  • KIR3DL2 protein, human
  • Ligands
  • Oligodeoxyribonucleotides
  • Receptors, KIR3DL1
  • Receptors, KIR3DL2