Robust Low-Dose CT Sinogram Preprocessing via Exploiting Noise-Generating Mechanism

IEEE Trans Med Imaging. 2017 Dec;36(12):2487-2498. doi: 10.1109/TMI.2017.2767290.

Abstract

Computed tomography (CT) image recovery from low-mAs acquisitions without adequate treatment is always severely degraded due to a number of physical factors. In this paper, we formulate the low-dose CT sinogram preprocessing as a standard maximum a posteriori (MAP) estimation, which takes full consideration of the statistical properties of the two intrinsic noise sources in low-dose CT, i.e., the X-ray photon statistics and the electronic noise background. In addition, instead of using a general image prior as found in the traditional sinogram recovery models, we design a new prior formulation to more rationally encode the piecewise-linear configurations underlying a sinogram than previously used ones, like the TV prior term. As compared with the previous methods, especially the MAP-based ones, both the likelihood/loss and prior/regularization terms in the proposed model are ameliorated in a more accurate manner and better comply with the statistical essence of the generation mechanism of a practical sinogram. We further construct an efficient alternating direction method of multipliers algorithm to solve the proposed MAP framework. Experiments on simulated and real low-dose CT data demonstrate the superiority of the proposed method according to both visual inspection and comprehensive quantitative performance evaluation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Animals
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Phantoms, Imaging
  • Radiation Dosage
  • Signal-To-Noise Ratio
  • Swine
  • Tomography, X-Ray Computed / methods*
  • Torso / diagnostic imaging