Elucidating the Skin Delivery of Aglycone and Glycoside Flavonoids: How the Structures Affect Cutaneous Absorption

Shih-Yi Chuang; Yin-Ku Lin; Chwan-Fwu Lin; Pei-Wen Wang; En-Li Chen; Jia-You Fang

doi:10.3390/nu9121304

Elucidating the Skin Delivery of Aglycone and Glycoside Flavonoids: How the Structures Affect Cutaneous Absorption

Nutrients. 2017 Nov 30;9(12):1304. doi: 10.3390/nu9121304.

Authors

Shih-Yi Chuang¹, Yin-Ku Lin^{2

3}, Chwan-Fwu Lin^{4

5}, Pei-Wen Wang⁶, En-Li Chen⁷, Jia-You Fang^{8

9

10

11}

Affiliations

¹ Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan 333, Taiwan. clemencechuang@gmail.com.
² Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung 204, Taiwan. lin1266@cgmh.org.tw.
³ School of Traditional Chinese Medicine, Chang Gung University, Kweishan, Taoyuan 333, Taiwan. lin1266@cgmh.org.tw.
⁴ Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan 333, Taiwan. cflin@mail.cgust.edu.tw.
⁵ Department of Cosmetic Science, Chang Gung University of Science and Technology, Kweishan, Taoyuan 333, Taiwan. cflin@mail.cgust.edu.tw.
⁶ Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan. pwwang@hotmail.com.
⁷ Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan 333, Taiwan. fajy5521@gmail.com.
⁸ Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan 333, Taiwan. fajy@mail.cgu.edu.tw.
⁹ Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan 333, Taiwan. fajy@mail.cgu.edu.tw.
¹⁰ Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan 333, Taiwan. fajy@mail.cgu.edu.tw.
¹¹ Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan 333, Taiwan. fajy@mail.cgu.edu.tw.

Abstract

Flavonoids are bioactive phytochemicals that exhibit protective potential against cutaneous inflammation and photoaging. We selected eight flavonoid aglycones or glycosides to elucidate the chemistry behind their skin absorption capability through experimental and computational approaches. The skin delivery was conducted using nude mouse and pig skins mounted on an in vitro Franz cell assembly. The anti-inflammatory activity was examined using the O₂^•.

MeSH terms

Administration, Cutaneous
Animals
Biological Transport
Female
Flavonoids / chemistry*
Flavonoids / pharmacokinetics*
Mice
Mice, Nude
Molecular Structure
Skin / metabolism*
Specific Pathogen-Free Organisms
Swine

Substances

Flavonoids