Objectives: To investigate the genetic polymorphism of DYS391 and other 23 Y-STR loci and to explore its application value in forensic science.
Methods: Y-STRs loci of 580 unrelated Han males in Nanjing were amplified using AGCU Y-PLUS PCR (24) kit. The genetic parameters of 24 Y-STR loci such as gene frequency were calculated by software, and compared with the data of Hubei, Liao- ning, Guangdong, Beijing and Chengdu Han population.
Results: Total 580 haplotypes were detected among 24 Y-STR loci in 580 unrelated Han males in Nanjing. The genetic diversity (GD) of each locus was from 0.294 6 to 0.939 8, and the haplotypes diversity (HD) was 0.983 7. There was a significant difference between the GD of 6 areas.
Conclusions: The 24 Y-STR loci such as DYS391 in Nanjing Han population have an application value in forensic science. They can also be used for cases testing and pedigree investigation.
Keywords: Han nationality; Y chromosome; forensic genetics; polymorphism, genetic; tandem repeat sequences.
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