Managing Persistent Hypoxemia: what is new?

Jesús Villar; Carlos Ferrando; Robert M Kacmarek

doi:10.12688/f1000research.11760.1

Managing Persistent Hypoxemia: what is new?

F1000Res. 2017 Nov 13:6:1993. doi: 10.12688/f1000research.11760.1. eCollection 2017.

Authors

Jesús Villar^{1

2

3}, Carlos Ferrando^{3

4}, Robert M Kacmarek^{5

6}

Affiliations

¹ Keenan Research Center for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.
² Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.
³ CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
⁴ Department of Anesthesiology, Hospital Clínico Universitario de Valencia, Valencia, Spain.
⁵ Department of Respiratory Care, Massachusetts General Hospital, Boston, Massuchusetts, USA.
⁶ Department of Anesthesiology, Harvard Medical School, Boston, Massuchusetts, USA.

Abstract

Mechanical ventilation is the standard life-support technique for patients with severe acute respiratory failure. However, some patients develop persistent and refractory hypoxemia because their lungs are so severely damaged that they are unable to respond to the application of high inspired oxygen concentration and high levels of positive end-expiratory pressure. In this article, we review current knowledge on managing persistent hypoxemia in patients with injured lungs.

Keywords: hypoxemia; mechanical ventilation; persistent hypoxemia; severe acute respiratory failure.

Publication types

Review

Grants and funding

This work was supported in part by grants from the Instituto de Salud Carlos III, Madrid, Spain (PI13/0119, PI14/00829, PI16/0049, CB06/06/1088) and by the Asociación Científica Pulmón y Ventilación Mecánica. CF is a recipient of a Start-up Young Investigator Award 2015 from the European Society of Anesthesiology.