Effect of Xylan Sulfates on Coagulation of Human Blood Plasma

N N Drozd; S A Kuznetsova; V A Levdansky; M A Mikhailenko

doi:10.1007/s10517-017-3947-z

Effect of Xylan Sulfates on Coagulation of Human Blood Plasma

Bull Exp Biol Med. 2017 Dec;164(2):158-161. doi: 10.1007/s10517-017-3947-z. Epub 2017 Nov 28.

Authors

N N Drozd¹, S A Kuznetsova^{2

3}, V A Levdansky², M A Mikhailenko⁴

Affiliations

¹ National Research Center for Hematology, Ministry of Health of the Russian Federation, Moscow, Russia. nndrozd@mail.ru.
² Institute of Chemistry and Chemical Technology, Siberian Division of the Russian Academy of Science, Subdivision of the Krasnoyarsk Federal Research Center, Krasnoyarsk, Russia.
³ Siberian Federal University, Krasnoyarsk, Russia.
⁴ Institute of Chemistry of Solid Body and Mechanochemistry, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia.

PMID: 29185171
DOI: 10.1007/s10517-017-3947-z

Abstract

Sulfated derivatives of xylan (isolated from Bétula pubéscens wood) with average molecular weight ~34 kDa, sulfur content of 11.3-17.5%, a degree of substitution of 0.74-1.64 are anticoagulants of direct type of action. Antithrombin and antifactor Xa activities in three tested xylan samples did not differ and reached 30.8-31.8 and 13.5-14.3 U/mg, respectively.

Keywords: anticoagulant; antithrombin activity; sulfatation; xylan.

MeSH terms

Anticoagulants / chemistry
Anticoagulants / isolation & purification
Anticoagulants / pharmacology*
Betula / chemistry
Blood Coagulation / drug effects
Blood Coagulation Tests
Factor Xa / metabolism*
Humans
Molecular Weight
Plant Extracts / chemistry
Sulfates / chemistry
Thrombin / antagonists & inhibitors*
Thrombin / metabolism
Xylans / chemistry
Xylans / isolation & purification
Xylans / pharmacology*

Substances

Anticoagulants
Plant Extracts
Sulfates
Xylans
Thrombin
Factor Xa