Abstract
Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions.
MeSH terms
-
Animals
-
DNA Breaks, Double-Stranded*
-
DNA Repair*
-
Models, Biological
-
RNA / genetics*
-
RNA / metabolism*
-
RNA Polymerase II / metabolism
-
RNA, Long Noncoding / genetics
-
RNA, Long Noncoding / metabolism
-
RNA, Small Untranslated / genetics
-
RNA, Small Untranslated / metabolism
Substances
-
RNA, Long Noncoding
-
RNA, Small Untranslated
-
RNA
-
RNA Polymerase II