RNA takes over control of DNA break repair

Nat Cell Biol. 2017 Nov 29;19(12):1382-1384. doi: 10.1038/ncb3645.

Abstract

Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions.

MeSH terms

  • Animals
  • DNA Breaks, Double-Stranded*
  • DNA Repair*
  • Models, Biological
  • RNA / genetics*
  • RNA / metabolism*
  • RNA Polymerase II / metabolism
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism
  • RNA, Small Untranslated / genetics
  • RNA, Small Untranslated / metabolism

Substances

  • RNA, Long Noncoding
  • RNA, Small Untranslated
  • RNA
  • RNA Polymerase II