Photomixotrophic chemical production in cyanobacteria

Morgan M Matson; Shota Atsumi

doi:10.1016/j.copbio.2017.11.008

Photomixotrophic chemical production in cyanobacteria

Curr Opin Biotechnol. 2018 Apr:50:65-71. doi: 10.1016/j.copbio.2017.11.008. Epub 2017 Nov 24.

Authors

Morgan M Matson¹, Shota Atsumi²

Affiliations

¹ Department of Chemistry, University of California, Davis, One Shields Ave, Davis, CA 95616, USA.
² Department of Chemistry, University of California, Davis, One Shields Ave, Davis, CA 95616, USA. Electronic address: satsumi@ucdavis.edu.

PMID: 29179151
DOI: 10.1016/j.copbio.2017.11.008

Abstract

The current global dependence on fossil fuels for both energy and chemical production has spurred concerns regarding long-term resource security and environmental detriments resulting from increased CO₂ levels. Through the installation of exogenous metabolic pathways, engineered cyanobacteria strains can directly fix CO₂ into industrially relevant chemicals currently produced from petroleum. This review highlights some of the studies that have successfully implemented photomixotrophic conditions to increase cyanobacterial chemical production. Supplementation with fixed carbon sources provides additional carbon building blocks and energy to enhance production and occasionally aid in growth. Photomixotrophic production has increased titers up to 5-fold over traditional autotrophic conditions, demonstrating promising applications for future commercialization.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biofuels*
Carbon Cycle
Carbon Dioxide / metabolism*
Cyanobacteria / growth & development
Cyanobacteria / metabolism*
Industrial Microbiology*
Metabolic Engineering / methods*
Metabolic Networks and Pathways*
Phototrophic Processes*

Substances

Biofuels
Carbon Dioxide