Cross-talk between protein synthesis, energy metabolism and autophagy in cancer

Lisa M Lindqvist; Kristofferson Tandoc; Ivan Topisirovic; Luc Furic

doi:10.1016/j.gde.2017.11.003

Cross-talk between protein synthesis, energy metabolism and autophagy in cancer

Curr Opin Genet Dev. 2018 Feb:48:104-111. doi: 10.1016/j.gde.2017.11.003. Epub 2017 Nov 25.

Authors

Lisa M Lindqvist¹, Kristofferson Tandoc², Ivan Topisirovic³, Luc Furic⁴

Affiliations

¹ Cell Signalling and Cell Death Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3050, Australia. Electronic address: lindqvist@wehi.edu.au.
² Lady Davis Institute, SMBD JGH, McGill University, Montreal, Quebec, Canada H3T 1E2; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H4A 3T2, Canada.
³ Lady Davis Institute, SMBD JGH, McGill University, Montreal, Quebec, Canada H3T 1E2; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H4A 3T2, Canada; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC H4A 3T2, Canada; Department of Biochemistry, McGill University, Montreal, QC H4A 3T2, Canada.
⁴ Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia; Cancer Program, Biomedicine Discovery Institute and Department of Anatomy & Developmental Biology, Monash University, Melbourne, VIC 3800, Australia. Electronic address: luc.furic@petermac.org.

Abstract

Translation is a pivotal step in the regulation of gene expression as well as one of the most energy consuming processes in the cell. Dysregulation of translation caused by the aberrant function of upstream signaling pathways and/or perturbations in the expression or function of components of the translation machinery is frequent in cancer. In this review, we discuss emerging findings that highlight hitherto unappreciated aspects of signaling to the translation apparatus with the particular focus on emerging connections between protein synthesis, autophagy and energy homeostasis in cancer.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autophagy*
Cell Nucleus / genetics
Energy Metabolism*
Humans
Mitochondrial Proteins / genetics
Neoplasms / metabolism*
Protein Biosynthesis*
Signal Transduction*

Substances

Mitochondrial Proteins

Grants and funding

R01 CA202021/CA/NCI NIH HHS/United States