Metabolic Regulation in Mitochondria and Drug Resistance

Yue Pan; Min Cao; Jianzhou Liu; Qing Yang; Xiaoyu Miao; Vay Liang W Go; Paul W N Lee; Gary Guishan Xiao

doi:10.1007/978-981-10-6674-0_11

Metabolic Regulation in Mitochondria and Drug Resistance

Adv Exp Med Biol. 2017:1038:149-171. doi: 10.1007/978-981-10-6674-0_11.

Authors

Yue Pan¹, Min Cao¹, Jianzhou Liu¹, Qing Yang¹, Xiaoyu Miao¹, Vay Liang W Go², Paul W N Lee³, Gary Guishan Xiao^{4

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Affiliations

¹ School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, China.
² Agi Hirshberg UCLA Center for Pancreas Diseases, University of California, Los Angeles, CA, USA.
³ Harbor University of California Los Angeles Medical Center, Torrance, CA, USA.
⁴ School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, China. gxiao@dlut.edu.cn.
⁵ Agi Hirshberg UCLA Center for Pancreas Diseases, University of California, Los Angeles, CA, USA. gxiao@dlut.edu.cn.
⁶ Harbor University of California Los Angeles Medical Center, Torrance, CA, USA. gxiao@dlut.edu.cn.
⁷ Functional Genomics and Proteomics Laboratories, Creighton University Medical Center, Omaha, NE, USA. gxiao@dlut.edu.cn.

PMID: 29178075
DOI: 10.1007/978-981-10-6674-0_11

Abstract

Mitochondria are generally considered as a powerhouse in a cell where the majority of the cellular ATP and metabolite productions occur. Metabolic rewiring and reprogramming may be initiated and regulated by mitochondrial enzymes. The hypothesis that cellular metabolic rewiring and reprogramming processes may occur as cellular microenvironment is disturbed, resulting in alteration of cell phenotype, such as cancer cells resistant to therapeutics seems to be now acceptable. Cancer metabolic reprogramming regulated by mitochondrial enzymes is now one of the hallmarks of cancer. This chapter provides an overview of cancer metabolism and summarizes progress made in mitochondria-mediated metabolic regulation in cancer drug resistance.

Keywords: Drug resistance; Metabolism; Mitochondrial; Signaling pathway.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adenosine Triphosphate* / genetics
Adenosine Triphosphate* / metabolism
Animals
Drug Resistance, Neoplasm / genetics*
Humans
Mitochondria* / genetics
Mitochondria* / metabolism
Mitochondria* / pathology
Neoplasms* / drug therapy
Neoplasms* / genetics
Neoplasms* / metabolism
Neoplasms* / pathology

Substances

Adenosine Triphosphate