Responsive complex capsules prepared with polymerization of dopamine, hydrogen-bonding assembly, and catechol dismutation

Jiaxing Sun; Chao Su; Xuejian Zhang; Jiefu Li; Wen-Bin Zhang; Ning Zhao; Jian Xu; Shuguang Yang

doi:10.1016/j.jcis.2017.10.021

Responsive complex capsules prepared with polymerization of dopamine, hydrogen-bonding assembly, and catechol dismutation

J Colloid Interface Sci. 2018 Mar 1:513:470-479. doi: 10.1016/j.jcis.2017.10.021. Epub 2017 Oct 7.

Authors

Jiaxing Sun¹, Chao Su¹, Xuejian Zhang², Jiefu Li¹, Wen-Bin Zhang³, Ning Zhao⁴, Jian Xu⁴, Shuguang Yang⁵

Affiliations

¹ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Center for Advanced Low-dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
² State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Center for Advanced Low-dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China; Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
³ Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
⁴ Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
⁵ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Center for Advanced Low-dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. Electronic address: shgyang@dhu.edu.cn.

PMID: 29175741
DOI: 10.1016/j.jcis.2017.10.021

Abstract

Complex capsules were fabricated by combining the polymerization of dopamine with hydrogen-bonding layer-by-layer assembly (LbL) of dopamine-modified poly(acrylic acid) (PAA-dopa) and poly(vinylpyrrolidone) (PVPON). PDA(PAA-dopa/PVPON)_n shell was cross-linked by dismutation reaction among catechol groups of polydopamine (PDA) and PAA-dopa. During LbL assembly, PAA-dopa and PVPON diffuse in the robust PDA pre-layer, and hence the complex capsules become soft and flexible. With the change of environmental pH value, the hydrogen bonds in PDA(PAA-dopa/PVPON)_n capsules would dissociate or reconstruct, and thus the complex capsules exhibit pH-responsive swelling-shrinking behavior. With only one assembled bilayer, PDA(PAA-dopa/PVPON)₁ capsules show a volume swelling ratio of 1.34 from pH 2.0 to pH 8.5. In addition, the complex capsules display controlled loading and release of Rhodamine 6G (R6G) as pH value changed, which can be considered as a potential candidate for drug delivery.

Keywords: Capsule; Hydrogen bond; Layer-by-layer assembly; Polydopamine.

MeSH terms

Capsules / chemistry*
Catechols / chemistry*
Dopamine / chemistry*
Drug Delivery Systems*
Fluorescent Dyes / metabolism
Hydrogen Bonding
Hydrogen-Ion Concentration
Polymerization
Rhodamines / metabolism*

Substances

Capsules
Catechols
Fluorescent Dyes
Rhodamines
rhodamine 6G
catechol
Dopamine