Comparison of the Cepheid GeneXpert CT/NG assay to the Hologic Aptima Combo2 assay for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in self-collected rectal swabs

Diagn Microbiol Infect Dis. 2018 Feb;90(2):83-84. doi: 10.1016/j.diagmicrobio.2017.10.013. Epub 2017 Oct 26.

Abstract

Self-collected rectal-swabs were tested for CT and NG on GeneXpert CT/NG as compared to APTIMA Combo2. Of 448 rectal-swabs, 22 were positive for CT; 7 for NG on both assays; two were discordant. Sensitivity and specificity of GeneXpert was 95.5% and 99.7% for chlamydia, respectively; for gonorrhea both were 100%.

Keywords: Chlamydia; Gonorrhea; NAATs; Rectal swabs.

Publication types

  • Comparative Study

MeSH terms

  • Chlamydia Infections / diagnosis*
  • Chlamydia Infections / microbiology
  • Chlamydia trachomatis / genetics*
  • Female
  • Gonorrhea / diagnosis*
  • Gonorrhea / microbiology
  • Humans
  • Male
  • Molecular Typing / methods*
  • Neisseria gonorrhoeae / genetics*
  • Nucleic Acid Amplification Techniques / methods*
  • Rectum / microbiology
  • Sensitivity and Specificity