Quasi-static pulmonary P-V curves of patients with ARDS, Part I: Characterization

Mohsen Nabian; Uichiro Narusawa

doi:10.1016/j.resp.2017.10.011

Quasi-static pulmonary P-V curves of patients with ARDS, Part I: Characterization

Respir Physiol Neurobiol. 2018 Jan:248:36-42. doi: 10.1016/j.resp.2017.10.011. Epub 2017 Nov 21.

Authors

Mohsen Nabian¹, Uichiro Narusawa¹

Affiliation

¹ Department of Mechanical and Industrial Engineering, Boston, MA, United States; Department of Bioengineering (affiliated), Northeastern University, Boston, MA, United States.

PMID: 29174041
DOI: 10.1016/j.resp.2017.10.011

Abstract

Quasi-static, pulmonary pressure-volume (P-V) curves are combined with a respiratory system model to analyze characteristics of patients with acute respiratory distress syndrome (ARDS). It is shown that there exist distinct differences between healthy- and injured-respiratory system in the order of magnitudes of parameters of their P-V model equation. Four stages of ARDS (Early ARDS, Deep knee, Advanced ARDS and Baby lung) are defined quantitatively in terms of these parameters.

Keywords: Acute lung injury (ALI); Acute respiratory distress syndrome (ARDS); Animal model; P–V curve; Recruitment; Respiratory system model (RSM).

MeSH terms

Animals
Humans
Lung Volume Measurements
Models, Biological*
Positive-Pressure Respiration*
Respiratory Distress Syndrome / physiopathology*
Respiratory Mechanics / physiology*