[Study on attenuating hepatotoxicity of Tripterygium wilfordii through compatibility of traditional Chinese medicine compound]

Zhongguo Zhong Yao Za Zhi. 2017 Aug;42(16):3044-3048. doi: 10.19540/j.cnki.cjcmm.20170714.011.
[Article in Chinese]

Abstract

With the deepening of the study of toxicology of traditional Chinese medicine, the mechanism of hepatotoxicity caused by Tripterygium wilfordii has been gradually revealed. As one of the characteristics of traditional Chinese medicine, Chinese medicine compatibility show its more reasonable and scientific effect in terms of reducing toxicity. In this paper, the author summarizes the research on the basis and mechanism of toxic substances in T. wilfordii, and sum up the compatibility of traditional Chinese medicine (preparation) to reduce its role of hepatotoxicity, so as to provide reference for the rationality and safety in clinical application of T. wilfordii, thereby reducing liver adverse reactions.

Keywords: Tripterygium wilfordii; compatible with attenuated; hepatotoxicity; mechanism.

MeSH terms

  • Chemical and Drug Induced Liver Injury*
  • Drug-Related Side Effects and Adverse Reactions*
  • Drugs, Chinese Herbal / toxicity*
  • Humans
  • Medicine, Chinese Traditional
  • Tripterygium / toxicity*

Substances

  • Drugs, Chinese Herbal