Abstract
In humans, the pathogenesis of diabetes is characterised by two major pancreatic β cell defects: a reduction in β cell mass and the failure of β cells to produce enough insulin. Over the past two decades, multiple studies involving cell cultures, animal models and human subjects have established the importance of the protein kinase RNA-like endoplasmic reticulum kinase (PERK) in the adaptive functional capacity of pancreatic β cells during embryonic development and into adulthood. In this review, we will highlight major findings identifying PERK as a crucial player in β cell physiology and in diabetes.
Keywords:
Apoptosis; Diseases; Endoplasmic reticulum; Pancreas; Peptide hormones/insulin.
© 2017 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.
MeSH terms
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Activating Transcription Factor 4 / genetics
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Activating Transcription Factor 4 / immunology
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Adult
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Animals
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Diabetes Mellitus, Experimental / enzymology
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Diabetes Mellitus, Experimental / genetics
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Diabetes Mellitus, Experimental / immunology
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Diabetes Mellitus, Experimental / pathology
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Diabetes Mellitus, Type 1 / enzymology
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Diabetes Mellitus, Type 1 / genetics*
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Diabetes Mellitus, Type 1 / immunology
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Diabetes Mellitus, Type 1 / pathology
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Diabetes Mellitus, Type 2 / enzymology
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Diabetes Mellitus, Type 2 / genetics*
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Diabetes Mellitus, Type 2 / immunology
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Diabetes Mellitus, Type 2 / pathology
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Epiphyses / abnormalities*
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Epiphyses / enzymology
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Epiphyses / immunology
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Epiphyses / pathology
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Eukaryotic Initiation Factor-2 / genetics*
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Eukaryotic Initiation Factor-2 / immunology
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Gene Expression Regulation, Developmental
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Homeostasis / genetics*
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Homeostasis / immunology
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Humans
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Infant, Newborn
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Insulin-Secreting Cells / enzymology*
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Insulin-Secreting Cells / immunology
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Insulin-Secreting Cells / pathology
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NF-E2-Related Factor 2 / genetics
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NF-E2-Related Factor 2 / immunology
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Osteochondrodysplasias / enzymology
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Osteochondrodysplasias / genetics*
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Osteochondrodysplasias / immunology
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Osteochondrodysplasias / pathology
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Signal Transduction
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eIF-2 Kinase / deficiency
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eIF-2 Kinase / genetics*
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eIF-2 Kinase / immunology
Substances
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ATF4 protein, human
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Eukaryotic Initiation Factor-2
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NF-E2-Related Factor 2
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NFE2L2 protein, human
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Activating Transcription Factor 4
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EIF2AK3 protein, human
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eIF-2 Kinase
Supplementary concepts
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Wolcott-Rallison syndrome