Re-cyclin' Cell-Cycle Components to Make NETs

Dev Cell. 2017 Nov 20;43(4):379-380. doi: 10.1016/j.devcel.2017.11.002.

Abstract

Neutrophil extracellular traps (NETs) are critical for the clearance of large pathogens and are also implicated in thrombosis, autoimmunity, and cancer. In this issue of Developmental Cell, Amulic et al. (2017) show that the terminally differentiated, non-cycling neutrophils repurpose cell-cycle proteins and pathways to form NETs.

Publication types

  • Review
  • Comment

MeSH terms

  • Autoimmunity / immunology*
  • Cell Cycle / physiology*
  • Cyclins / metabolism*
  • Extracellular Traps / metabolism
  • Humans
  • Neutrophil Activation / immunology
  • Proliferating Cell Nuclear Antigen / immunology*
  • Thrombosis / immunology
  • Thrombosis / metabolism

Substances

  • Cyclins
  • Proliferating Cell Nuclear Antigen