Localized Lysosome Exocytosis Helps Breach Tissue Barriers

Shaohe Wang; Kenneth M Yamada

doi:10.1016/j.devcel.2017.11.005

Localized Lysosome Exocytosis Helps Breach Tissue Barriers

Dev Cell. 2017 Nov 20;43(4):377-378. doi: 10.1016/j.devcel.2017.11.005.

Authors

Shaohe Wang¹, Kenneth M Yamada²

Affiliations

¹ Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. Electronic address: shaohe.wang@nih.gov.
² Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. Electronic address: kenneth.yamada@nih.gov.

PMID: 29161585
DOI: 10.1016/j.devcel.2017.11.005

Abstract

Cell invasion across basement membrane barriers is important in both normal development and cancer metastasis. In this issue of Developmental Cell, Naegeli et al. (2017) identify a mechanism for breaching basement membranes. Localized lysosome exocytosis fuels generation of large, invasive cellular protrusions that expand tiny basement membrane openings.

Published by Elsevier Inc.

Publication types

Review
Comment

MeSH terms

Actins / metabolism
Animals
Basement Membrane / metabolism
Caenorhabditis elegans
Caenorhabditis elegans Proteins / metabolism*
Cell Movement / physiology*
Exocytosis / physiology*
Humans
Lysosomes / metabolism*

Substances

Actins
Caenorhabditis elegans Proteins