A Metal-Organic Framework with Exceptional Activity for C-H Bond Amination

Le Wang; Douglas W Agnew; Xiao Yu; Joshua S Figueroa; Seth M Cohen

doi:10.1002/anie.201709420

A Metal-Organic Framework with Exceptional Activity for C-H Bond Amination

Angew Chem Int Ed Engl. 2018 Jan 8;57(2):511-515. doi: 10.1002/anie.201709420. Epub 2017 Dec 13.

Authors

Le Wang¹, Douglas W Agnew¹, Xiao Yu², Joshua S Figueroa¹, Seth M Cohen¹

Affiliations

¹ Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
² Department of Nanoengineering, University of California, San Diego, La Jolla, CA, 92093, USA.

PMID: 29160961
DOI: 10.1002/anie.201709420

Abstract

The development of catalysts capable of fast, robust C-H bond amination under mild conditions is an unrealized goal despite substantial progress in the field of C-H activation in recent years. A Mn-based metal-organic framework (CPF-5) is described that promotes the direct amination of C-H bonds with exceptional activity. CPF-5 is capable of functionalizing C-H bonds in an intermolecular fashion with unrivaled catalytic stability producing >10⁵ turnovers.

Keywords: amination; heterogeneous catalysis; manganese; metal-organic frameworks; nitrenes.

Publication types

Retracted Publication