Bleomycin-induced flagellate erythema after venous malformation sclerosis-Case report and brief review

Pediatr Dermatol. 2018 Jan;35(1):e5-e8. doi: 10.1111/pde.13297. Epub 2017 Nov 21.

Abstract

Bleomycin-induced flagellate erythema is a rare but typical skin toxicity of bleomycin. We report the case of a boy with a left foot venous malformation who developed this skin rash after two sessions of bleomycin intralesional injection. We discuss the mechanism and characteristics of this reaction to bleomycin, which is usually benign and self-limited. We conclude that, although rare, flagellate pigmentation can occur when bleomycin is used as a sclerosant in children.

Keywords: drug reaction; vascular malformation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Antibiotics, Antineoplastic / adverse effects*
  • Bleomycin / adverse effects*
  • Drug Eruptions / diagnosis*
  • Drug Eruptions / drug therapy
  • Erythema / chemically induced
  • Glucocorticoids / therapeutic use
  • Histamine Antagonists / therapeutic use
  • Humans
  • Injections, Intralesional
  • Magnetic Resonance Imaging
  • Male
  • Skin / pathology
  • Vascular Malformations / drug therapy*

Substances

  • Antibiotics, Antineoplastic
  • Glucocorticoids
  • Histamine Antagonists
  • Bleomycin