New cyclic sulfides extracted from Allium sativum: garlicnins P, J2, and Q

Toshihiro Nohara; Masateru Ono; Naho Nishioka; Fuka Masuda; Yukio Fujiwara; Tsuyoshi Ikeda; Daisuke Nakano; Junei Kinjo

doi:10.1007/s11418-017-1151-0

New cyclic sulfides extracted from Allium sativum: garlicnins P, J₂, and Q

J Nat Med. 2018 Jan;72(1):335-341. doi: 10.1007/s11418-017-1151-0. Epub 2017 Nov 20.

Authors

Toshihiro Nohara¹, Masateru Ono², Naho Nishioka², Fuka Masuda², Yukio Fujiwara³, Tsuyoshi Ikeda⁴, Daisuke Nakano⁵, Junei Kinjo⁵

Affiliations

¹ Faculty of Pharmaceutical Sciences, Sojo University, 4-22-2 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan. none@ph.sojo-u.ac.jp.
² School of Agriculture, Tokai University, 5435 Minamiaso, Aso, Kumamoto, 869-1404, Japan.
³ Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
⁴ Faculty of Pharmaceutical Sciences, Sojo University, 4-22-2 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan.
⁵ Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.

PMID: 29159686
DOI: 10.1007/s11418-017-1151-0

Abstract

Two atypical cyclic-type sulfides, garlicnin P (1) and garlicnin J₂ (2), and one thiabicyclic-type sulfide, garlicnin Q (3), were isolated from the acetone extracts of garlic, Allium sativum, bulbs cultivated in the Kumamoto city area, and their structures characterized. Their production pathways are also discussed.

Keywords: Allium sativum; Atypical cyclic-type sulfide; Garlicnin J2; Garlicnin P; Garlicnin Q; Thiabicyclic-type sulfide.

MeSH terms

Acetone / chemistry
Disulfides / chemistry
Disulfides / isolation & purification*
Garlic / chemistry
Molecular Conformation
Plant Extracts / chemistry
Plant Extracts / isolation & purification*
Plant Roots / chemistry
Solvents / chemistry
Thiophenes / chemistry
Thiophenes / isolation & purification*

Substances

Disulfides
Plant Extracts
Solvents
Thiophenes
Acetone